Janelia Conference- The Role of Adhesion Complexes, Cell Recognition, and Neural Activity during Circuit Assembly
One event on May 22, 2023 at 12:00 am
One event on May 23, 2023 at 12:00 am
One event on May 24, 2023 at 12:00 am
This meeting will focus on molecular and cellular mechanisms underlying the formation of precise patterns of synaptic connectivity. Over the past decade, considerable progress has been made in uncovering the molecular identity and structure of adhesion complexes at synapses, diverse cell surface recognition molecules contributing to wiring specificity, and the role of activity in sculpting the neural circuitry. In parallel, detailed connectomics at the light microscopy and EM level have uncovered the extraordinary specificity and complexity of connectivity, and single cell sequencing has defined cell types and cell-type specific patterns of cell-surface protein expression during circuit assembly. Light microscopic techniques from super-resolution to expansion microscopy and live imaging have led to important advances in uncovering cell biological mechanisms of circuit assembly. Presentations and discussions will highlight important advances in the field and consider current challenges and future directions.